RAF Typhoon jets have operated alongside France's air force in a combined operation on an subterranean weapons facility in Syrian territory operated by the Daesh militant organization, according to the British defence ministry.
The facility, pinpointed through intelligence, was assessed as containing munitions and bombs, the release indicated, and was positioned in hills just north of the historic site of Palmyra in central Syria.
"Our aircraft used precision-guided Paveway IV munitions to hit a series of entry passages down to the site... early reports are that the strike was effective," the MoD said.
There was no evidence of any harm to civilians in the strike late on Saturday and each participating jet returned safely, the MoD added.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - also known as Daesh - established militant control over large swathes of both Syria and Iraq until 2019.
"This operation underscores our UK leadership, and determination to operate in unison with our allies, to eradicate any resurgence of IS and their harmful and extremist ideologies in the Middle East," the British Defence Secretary John Healey remarked.
British military aircraft have carried out surveillance missions over Syrian airspace to "prevent any attempted comeback" of the group following its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of the UK armed forces participating in this operation for their professionalism and their valour," Healey said. "Including them were numerous British personnel stationed over the holidays. This mission, to eliminate terrorist threats who pose a risk to our safety, demonstrates how our armed forces are prepared to act, continuously, ensuring Britain's security within its borders and strong abroad."
During December, the American forces executed what it called a "major assault" against IS targets in the country, following an attack claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. estimates IS still boasts between 5,000 and 7,000 militants in Syria and Iraq.